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    徐凯林 讲师

    作者: 时间:2019-01-01 点击数:

     

     

    徐凯林 博士 讲师

    所属学院:生物医药学院

    Email: xukailin@gdut.edu.cn, 953105874@qq.com

    主要研究领域为新型药剂学:

    1、药物固态形式多样化及其药学性质研究。包括研究药物同质多晶、无定型亚博棋牌游戏官网、共晶及其药学性质等,重点在糖尿病药物优势晶型设计/控制策略的研发;此研究可在不引入药物非活性成分的前提下弥补药物缺陷,获得优势新晶型,从原料药源头改善药物品质;

    2、新型抗癌组合疗法多功能复合纳米材料的设计研究。基于肿瘤微环境的特点亚博棋牌游戏官网,设计逐级响应的抗癌组合疗法多功能复合纳米粒子亚博棋牌游戏官网,弥补化疗药物强烈的毒副作用弱点,利用现代新型组合技术实现精准靶向抗癌。

    个人简述:徐凯林博士,广东工业大学生物医药学院讲师,为广东工业大学“青年百人计划”引进人才,广东工业大学制药工程系教师。任职于广东工业大学天然药物与绿色化学研究所、广东省药食同源综合利用与研究开发工程中心,Allan H. Conney新药研发联合实验室。近年来主要从事新型药剂学的研究,包括研究药物同质多晶亚博棋牌游戏官网、优势晶型、无定型、共晶及其药学性质等,重点在糖尿病药物优势晶型设计/控制策略的研发亚博棋牌游戏官网;新型抗癌组合疗法多功能复合纳米材料的设计研究;以及天然植物抗癌药物的发现和作用机制研究。迄今为止,已在包括Journal of cleaner production亚博棋牌游戏官网, International journal of pharmaceutics, CrystEngComm, Analyst, Journal of pharmaceutical and biomedical analysis,Journal of pharmaceutical sciences等一系列SCI期刊上发表学术论文三十余篇(其中第一作者或通讯作者发表SCI论文8篇)。

    教育背景:

    2014.09-2017.06四川大学    制药工程专业    博士;

    2011.09-2014.06:四川大学     制药工程专业    硕士;

    2007.09-2011.06:怀化学院     制药工程专业    学士。

    工作经历:

    2017.07-至今广东工业大学青年百人引进人才,制药工程系;

    2018.03-2019.03:香港大学,李嘉诚医学院,访问学者。

    主要论文:

    1. Jiewu Leng, Pingyu Jiang, Kailin Xu*, Qiang Liu, J. Leon Zhao, Yiyang Bian, Rui Shi. Makerchain: A blockchain with chemical signature for self-organizing process in social manufacturing [J]. Journal of Cleaner Production, 2019, 234, 767-778. (, Top, IF=6.395, 通讯作者)

    2. Xu Kailin, Zheng Shoujun, Zhai Yuanming, et al. Two solid forms of tauroursodeoxycholic acid and the effects of milling and storage temperature on solid-state transformations [J]. International journal of pharmaceutics, 2015, 486(1), 185-194. (II, Top, IF=4.213, 第一作者)

    3. Xu Kailin, Xiong Xinnuo, Li Shanshan, et al. New polymorph of glipizide with enhanced properties obtained using environmentally friendly methods [J]. CrystEngComm, 2016, 18, 4508–4512. (II, IF=4.034, 第一作者)

    4. Xu Kailin, Liang Bin, Li Yanfang, et al. Injection-ultrasound-assisted emulsification microextraction based on using low-density organic solvent followed by high-performance liquid chromatography for the determination of pyrethroids in water samples[J]. Analyst, 2013, 138(4), 1262-1270. (II, IF= 4.019, 第一作者)

    5. Xu Kailin, Xiong Xinnuo, Zhai Yuanming, et al. Effect of milling conditions on solid-state amorphization of glipizide, and characterization and stability of solid forms [J]. Journal of Pharmaceutical and Biomedical Analysis, 2016, 129: 367-377. (II, IF= 3.169, 第一作者)

    6. Xu Kailin, Zheng Shoujun, Guo Liuqi, et al. Four solid forms of tauroursodeoxycholic acid and solid-state transformations: effects of temperature and milling [J]. RSC Advances, 2015, 5(117), 96392-96403. (II, IF= 3.840, 第一作者)

    7. Xu Kailin, Xiong Xinnuo, Guo Liuqi, et al. An Investigation into the Polymorphism and Crystallization of Levetiracetam and the Stability of its Solid Form [J]. Journal of pharmaceutical sciences, 2015, 104(12), 4123-4131. (III, IF= 3.007, 第一作者)

    8. Xu Kailin, Liang Bin, Wu Xiaoqing, et al. X-ray powder diffraction data for levetiracetam [J]. Powder Diffraction, 2014, 29(01), 51-52. (IV, IF= 0.586, 第一作者)

    9. Xiao Yin, Xu Kailin, Wang Qing, et al. Synthesis, structure, and calf-thymus DNA binding of ternary fleroxacin–Cu (II) complexes[J]. RSC Advances, 2016, 6(83): 80286-80295.

    10. Li Zhenzhen, Xu Kailin, Liang Bin, et al. Determination of trace tetracyclines in surface water by aluminum hydroxide coprecipitation coupled with high-performance liquid chromatography [J]. Analytical Methods, 2013, 5(14), 3516-3522.

    11. Cheng Yuan, Xu Kailin, Li Hui, et al. Preparation of Urea-Imprinted Cross-Linked Chitosan and Its Adsorption Behavior [J]. Analytical Letters, 2014, 47(6), 1063-1078.

    12. Li Xiangling, Xu Kailin, Li Hui, et al. Qualitative analysis of chiral alanine by UV-visible-shortwave near infrared diffuse reflectance spectroscopy combined with chemometrics [J]. RSC Advances, 2016, 6(10), 8395-8405.

    13. Guo Liuqi, Xu Kailin, Ma Xiaoli, et al. X-ray powder diffraction data for niclosamide [J], Powder Diffraction, 2015, 30, 375-377.

    14. Xiong Xinnuo, Xu Kailin, Li Shanshan, et al. Solid-state amorphization of rebamipide and investigation on solubility and stability of the amorphous form [J], Drug Development and Industrial Pharmacy, 2016, 1-10.

    15. Xiong Xinnuo, Xu Kailin, Du Qiaohong, et al. Effects of Temperature and Solvent on the Solid-State Transformations of Pranlukast during Mechanical Milling [J], Journal of Pharmaceutical Sciences, 2017, doi 10.1016/j.xphs.2017.02.020.

    16. Zou Huayu, Xu Kailin, Feng Yuyan, et al. Application of first order derivative UV spectrophotometry coupled with H-point standard addition to the simultaneous determination of melamine and dicyandiamide in milk[J]. Food analytical methods, 2015, 8(3), 740-748.

     

    教学活动:主要从事制药工程相关的专业课程亚博棋牌游戏官网,如《制药过程安全与环毖遣┢迮朴蜗饭偻?亚博棋牌游戏官网!?、《药物合成反应》亚博棋牌游戏官网、《制药工程专业实验》等课程的理论教学及实践教学。

    我的团队:本团队隶属于“广工大绿色化学与天然药物研究所”、“广工大Allan Conney抗肿瘤药物实验室”以及“广东省药食同源植物资源开发与利用工程中心”。

     

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